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Related Experiment Video

Updated: Jan 17, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Defining Fecal Calprotectin Cutoffs That Predict Endoscopic and Histologic Remission in Patients With Ulcerative

Gustavo Drügg Hahn1,2,3, Peter Laszlo Lakatos1,4, Chelsea Maedler-Kron5

  • 1Division of Gastroenterology, Department of Medicine, McGill University, Montreal, QC, Canada.

Inflammatory Bowel Diseases
|September 19, 2025
PubMed
Summary

Fecal calprotectin levels correlate with ulcerative colitis disease activity. This study establishes optimal cutoff values for fecal calprotectin to identify histoendoscopic remission in patients with ulcerative colitis.

Keywords:
endoscopic remissionfecal calprotectinhistologic remissionulcerative colitis

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Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Clinical Biomarker Studies

Background:

  • Fecal calprotectin is a key marker for ulcerative colitis (UC) activity.
  • Consensus cutoff values for histoendoscopic remission are lacking.
  • This study correlates fecal calprotectin with endoscopic and histologic UC activity.

Purpose of the Study:

  • To establish optimal fecal calprotectin cutoff values for assessing histoendoscopic remission in UC patients.
  • To correlate fecal calprotectin levels with Mayo endoscopic score and Geboes histological score.
  • To evaluate fecal calprotectin as a surrogate marker for UC disease activity.

Main Methods:

  • Prospective study of 253 adult UC patients (2013-2020).
  • Collected fecal calprotectin and Mayo endoscopic scores during colonoscopy.
  • Assessed histological activity using the Geboes score by a blinded pathologist.

Main Results:

  • Fecal calprotectin ≥ 123 μg/g predicts Mayo endoscopic score > 0 (58% sensitivity, 70% specificity).
  • Fecal calprotectin ≥ 80 μg/g identifies Geboes score > 3.1 in clinically remitting patients (64.7% sensitivity, 58.7% specificity).
  • Fecal calprotectin ≥ 50 μg/g is optimal for identifying active histologic inflammation (Geboes score > 2) in clinical remission (49.6% sensitivity, 41.6% specificity).

Conclusions:

  • Fecal calprotectin effectively correlates with endoscopic and histologic disease activity in UC.
  • Established optimal fecal calprotectin cutoff values can discriminate histoendoscopic remission.
  • Fecal calprotectin serves as a valuable surrogate marker for UC disease activity assessment.