Halophosphonium Salts-Mediated Photochemical C(sp3)-H Functionalization
Kaiting Sun1, Xun Yang1, Youyou Zheng1
1College of Medicine, Jiaxing University, 118 Jiahang Road, Jiaxing 314001, P. R. China.
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Herein we report a method that uses halophosphonium salts as dual-function reagents for versatile C(sp3)-H functionalization under visible light. They serve simultaneously as photocatalysts and hydrogen atom transfer reagents, eliminating the need for exogenous metal catalysts. This strategy enables benzylic, allylic, and aliphatic C-H alkylation, hydrazination, and cyanation. The discovery significantly expands the synthetic utility of halophosphonium salts beyond their classical roles, establishing them as modular photochemical scaffolds for green organic synthesis.
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