Anticancer Bioactive Peptides from Plants: Sources, Action Mechanisms, and Potential Superiority to Conventional Chemotherapy
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Plant-derived anticancer peptides (PDACPs) offer a promising, safer alternative to conventional cancer treatments. These natural compounds exhibit high specificity and multi-target mechanisms, showing potential to overcome drug resistance and reduce side effects.
Area Of Science
- Biochemistry
- Pharmacology
- Molecular Biology
Background
- Cancer poses a significant global health burden, with current therapies limited by side effects, resistance, and cost.
- Plant-derived anticancer peptides (PDACPs) present a novel therapeutic avenue due to their specificity, multi-target actions, and favorable safety profiles.
Purpose Of The Study
- To review the sources, mechanisms of action, and therapeutic potential of PDACPs.
- To highlight PDACPs' roles in inducing apoptosis, cell cycle arrest, inhibiting angiogenesis, and preventing metastasis.
- To discuss challenges and strategies for enhancing the clinical viability of PDACPs.
Main Methods
- Literature review of studies on plant-derived anticancer peptides.
- Analysis of mechanistic investigations into PDACP action.
- Evaluation of preclinical data comparing PDACPs with conventional chemotherapeutics.
Main Results
- PDACPs induce apoptosis via mitochondrial disruption and upregulate pro-apoptotic factors.
- PDACPs inhibit proliferation by arresting cell-cycle progression.
- PDACPs suppress angiogenesis by downregulating VEGF signaling and disrupt tumor membrane integrity.
- Preclinical data indicate enhanced tumor selectivity and reduced toxicity for PDACPs compared to chemotherapy.
Conclusions
- PDACPs demonstrate significant potential as next-generation anticancer agents.
- Strategies like nanoparticle encapsulation can improve peptide stability and delivery for clinical application.
- Further translational development is warranted to realize the full therapeutic promise of PDACPs.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Tumors may result in a case where two people have the same mutations in an oncogene or tumor...
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.