Risk Factors for Readmissions in Patients Undergoing Endoscopic Drainage for Peripancreatic Fluid Collections

Pancreatic fluid collections (PFCs) are a frequent complication following acute pancreatitis and often necessitate endoscopic cystogastrostomy (EC) for drainage. Despite high technical and clinical success rates, unplanned readmissions remain common.

This study aimed to evaluate readmission rates and identify associated risk factors in patients undergoing EC for PFCs.

We conducted a retrospective review of 100 patients who underwent EC for symptomatic PFCs between June 2016 and August 2021. Demographic data, clinical characteristics, procedural details, and outcomes were analyzed. Univariate and multivariate logistic regression were used to identify factors associated with unplanned readmissions.

Clinical success was achieved in 95% of patients. However, 31% experienced unplanned readmissions, most commonly due to sepsis (47%), abdominal pain (28%), and gastrointestinal bleeding (14%). Univariate analysis identified intra-abdominal varices and paracolic gutter extension as significant risk factors. Multivariate analysis confirmed intra-abdominal varices as an independent predictor (OR 3.51, 95% CI 1.26-9.80, P = 0.016). Technical success was high (98%) with an overall adverse event rate of 14%.

Unplanned readmissions are common after EC for PFCs, with intra-abdominal varices emerging as a key risk factor. Enhanced follow-up and risk stratification may improve patient outcomes and reduce healthcare burden.