Functional Properties of the Hydroethanolic Extracts and Main Phenolics of Lactarius indigo and Amanita jacksonii: Millenary Mushrooms Consumed in the Northeastern Highlands of Puebla, Mexico
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View abstract on PubMed
Summary
This summary is machine-generated.Edible mushrooms Lactarius indigo and Amanita jacksonii possess nutraceutical properties due to their phenolic compounds. These mushrooms exhibit cholesterol-lowering, anti-proliferative, and triglyceride-reducing effects.
Area Of Science
- * Food Science and Nutraceuticals
- * Medicinal Mycology
- * Biochemistry
Background
- * Edible mushrooms are recognized for their health benefits and bioactive compounds.
- * Lactarius indigo and Amanita jacksonii are consumed in Mexico but their nutraceutical properties are not well-documented.
- * Phenolic compounds are known for their diverse biological activities.
Purpose Of The Study
- * To investigate the nutraceutical properties of Lactarius indigo and Amanita jacksonii.
- * To identify and quantify phenolic compounds in mushroom extracts.
- * To evaluate the hypocholesterolemic, anti-proliferative, and anti-hypertriglyceridemic effects of these mushrooms and their isolated compounds.
Main Methods
- * Hydroethanolic extraction of mushroom samples.
- * High-Performance Liquid Chromatography with Diode-Array Detection and Mass Spectrometry (HPLC-DAD/MS) for phenolic compound analysis.
- * In vitro enzyme inhibition assays (HMG-CoA reductase, ornithine decarboxylase, pancreatic lipase).
- * In vivo studies on ICR mice fed hypercaloric and high-fat diets.
- * Cell viability assays (DLD-1).
Main Results
- * Lactarius indigo extract contained seven phenolics, with protocatechuic acid (PCA) as the major compound (52.9 mg/100 g DW).
- * Amanita jacksonii extract contained nine phenolics, with p-hydroxybenzoic acid (HBA) as the main compound (47.3 mg/100 g DW).
- * L. indigo extract and PCA inhibited HMG-CoA reductase and ornithine decarboxylase.
- * A. jacksonii extract and HBA inhibited pancreatic lipase.
- * In vivo studies confirmed hypocholesterolemic and anti-hypertriglyceridemic effects.
- * Antiproliferative effects were observed in DLD-1 cells.
Conclusions
- * The nutraceutical properties of Lactarius indigo and Amanita jacksonii are attributed to their phenolic content.
- * Protocatechuic acid and p-hydroxybenzoic acid are key bioactive compounds responsible for observed health benefits.
- * These mushrooms represent a valuable source of natural compounds for functional foods and potential therapeutic agents.
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