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Related Experiment Video

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Developing and validating an elderly brain template: A comprehensive comparison with MNI152 for age-specific

Kazumichi Ota1, Yoshihiko Nakazato1, Genko Oyama1

  • 1Department of Neurology, Faculty of Medicine, Saitama Medical University, Iruma-gun, Saitama 350-0495, Japan.

Neuroimage
|September 20, 2025
PubMed
Summary

A new Elderly brain template improves spatial normalization for older adults, outperforming the standard MNI152 template. This enhances age-specific neuroimaging analysis and research into neurodegenerative diseases.

Keywords:
AtrophyElderly brain templateJapanMNI152Neurodegenerative diseasesNeuroimaging

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Area of Science:

  • Neuroimaging
  • Brain Anatomy
  • Geriatric Medicine

Background:

  • The standard Montreal Neurological Institute 152 (MNI152) brain template is based on young adults.
  • This template may not accurately represent age-related brain morphology changes.
  • An "Elderly" template was developed to address this limitation.

Purpose of the Study:

  • To develop and validate a new brain template optimized for older adults.
  • To compare the spatial normalization accuracy of the Elderly template against the MNI152 template.
  • To assess the template's performance across different brain tissues and subcortical regions.

Main Methods:

  • Constructed the Elderly template using MRI scans from 90 OASIS-1 participants matching Japanese census demographics.
  • Compared spatial normalization accuracy with the MNI152 template using the IXI dataset.
  • Analyzed 282 scans (ages 20-80+) from UK Biobank, assessing whole-brain similarity (CC, MSE, 3D-SSIM) and regional Dice coefficients (WM, GM, CSF, subcortical regions).

Main Results:

  • Significant Age × Template interactions were found for cross-correlation and mean-squared error (p < 0.001).
  • Cerebrospinal fluid showed notable differences in individuals aged 60 and older.
  • The Elderly template demonstrated the greatest improvement in subcortical regions like the caudate, thalamus, hippocampus, and amygdala.

Conclusions:

  • The Elderly template provides more accurate spatial normalization for older adults compared to the MNI152 template.
  • This improved accuracy facilitates more precise age-specific neuroimaging analyses.
  • The Elderly template holds potential for advancing neurodegenerative disease research and clinical applications.