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Murine Kidney Transplant Technique
Published on: October 20, 2015
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Kidney Transplantation Using High-Vascular-Resistant Renal Allografts From a Donor Who Had Calcineurin-Induced
S Li1, C A Hostetler1, J B Nave1
1LifeShare Network, Oklahoma City, OK.
Transplantation Proceedings
|September 20, 2025
Summary
High renal vascular resistance in kidney allografts during hypothermic machine perfusion (HMP) can be overcome. Two kidneys from a donation after circulatory death donor, despite high resistance, were successfully transplanted, demonstrating the viability of such organs for recipients.
Area of Science:
- Nephrology
- Transplantation immunology
- Organ preservation
Background:
- High renal vascular resistance (RR) during hypothermic machine perfusion (HMP) often leads to the decline of kidney allografts.
- This case report addresses the successful transplantation of two such kidneys with elevated RR.
Purpose of the Study:
- To report the successful transplantation of kidney allografts with high renal vascular resistance (RR) during hypothermic machine perfusion (HMP).
- To investigate the potential of using kidneys from donors with functional acute kidney injury (AKI) induced by calcineurin inhibitors (CNIs).
Main Methods:
- Procurement of two kidneys from a donation after circulatory death (DCD) donor with functional AKI due to CNI therapy.
- Assessment of renal vascular resistance (RR) after 29 hours of HMP.
- Successful transplantation of both allografts.
Main Results:
- Both kidney allografts with high preimplant RR were successfully transplanted, with recipients discharged without oliguria.
- Recipient creatinine levels showed improvement post-transplant, indicating good graft function.
- One kidney experienced delayed graft function (DGF) but did not require post-discharge dialysis.
Conclusions:
- Kidney allografts exhibiting high RR during HMP can be successfully transplanted.
- Functional AKI induced by CNIs in donors may not preclude successful transplantation.
- HMP assessment of RR can be a valuable tool in evaluating kidney allograft viability.
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