Reticulocalbin-1 in clear cell renal cell carcinoma: clinical and functional evidence for its role as a biomarker and potential therapeutic target
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View abstract on PubMed
Summary
This summary is machine-generated.Reticulocalbin-1 (RCN1) is highly expressed in clear-cell renal cell carcinoma (ccRCC) and linked to poorer survival. Targeting RCN1 may offer new therapeutic strategies for ccRCC patients.
Area Of Science
- Oncology
- Molecular Biology
- Cancer Research
Background
- Clear-cell renal cell carcinoma (ccRCC) is the most common kidney cancer subtype with poor metastatic prognosis.
- Reticulocalbin-1 (RCN1), an endoplasmic reticulum protein, is implicated in aggressiveness in other cancers but its role in ccRCC is unstudied.
Purpose Of The Study
- To investigate the expression and prognostic significance of RCN1 in ccRCC.
- To explore the potential of RCN1 as a diagnostic biomarker and therapeutic target in ccRCC.
Main Methods
- In-silico analysis of transcriptomic data and a large cohort study of 306 ccRCC patients.
- Correlation analysis of RCN1 expression with clinicopathological parameters, overall survival, and immune cell infiltration (CD8 T-lymphocytes, macrophages).
- In vitro functional assays involving RCN1 silencing in ccRCC cell lines to assess effects on tumor cell behavior.
Main Results
- RCN1 is highly expressed at both mRNA and protein levels in ccRCC, confirmed in 63.7% of cases.
- High RCN1 expression significantly correlates with shorter overall survival, higher tumor grade, advanced stage, and presence of metastases.
- RCN1 silencing reduced tumor cell migration and invasion, with a trend towards correlation with macrophage infiltration.
Conclusions
- RCN1 is a significant prognostic marker in ccRCC, associated with aggressive disease.
- RCN1 warrants further investigation as a potential therapeutic target for improving ccRCC patient outcomes.
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