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Inhibitory effects against SARS-COV-2 main protease of terpenic substances and selenated naphthoquinones
Marcos R Scheide1, Tiago Tizziani1, Gabriella B Souza1
1Department of Chemistry, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Abstract:
Clinical studies on COVID-19 patients revealed among multiple symptoms, uncontrolled production of inflammatory mediators. The current study presents the inhibitory effects of eleven terpenoid derivatives (1-11) and two naphthoquinones (12 and 13) on the main protease (Mpro) of SARS-CoV-2. All the terpenoids and compound 13 displayed weak inhibitory effects while compound 12 showed moderate inhibitory effects of Mpro with IC50 of 50.2 µM. Anti-inflammatory effects against pro-inflammatory mediators produced in LPS-induced lung injury and the cytotoxicity against Vero and THP-1 cell lines of molecules 12 and 13 were also evaluated. Molecules 12 and 13 presented promising anti-inflammatory activity by attenuating the exudation and neutrophil and leukocyte migration.
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