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Updated: Jan 17, 2026
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Removal and Replacement of Endogenous Ligands from Lipid-Bound Proteins and Allergens
Published on: February 24, 2021
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Food allergen-polysaccharide interaction: Structure, characterization, digestion, and allergenicity
Wanglong Yu1, Wei Hu1, Ziwen Hao1
1State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China; College of Food Science and Technology, Nanchang University, Nanchang 330031, China.
Food Chemistry
|September 21, 2025
Summary
Polysaccharides show promise in combating food allergies by interacting with allergens. They modify allergen structure and digestibility, and influence immune responses and gut microbiota for potential anti-allergy applications.
Area of Science:
- Food science
- Immunology
- Microbiology
Background:
- Rising global food allergy prevalence necessitates novel anti-allergy strategies.
- Polysaccharides possess structural versatility and bioactive properties relevant to allergy modulation.
- Understanding polysaccharide-allergen interactions is key to developing dietary interventions.
Purpose of the Study:
- To review the characteristics of polysaccharides and allergens.
- To elucidate the mechanisms of polysaccharide-allergen interactions.
- To explore the anti-allergy potential of polysaccharides.
Main Methods:
- Literature review on polysaccharide classification, structure, and properties.
- Analysis of covalent and non-covalent interactions between polysaccharides and allergens.
- Examination of polysaccharide effects on allergen structure, epitopes, and digestibility.
- Review of indirect mechanisms involving immune cell modulation and gut microbiota alteration.
Main Results:
- Polysaccharides can alter allergen secondary structure and epitopes via glycation.
- Formation of polysaccharide-protein gels reduces allergen digestibility and allergenic activity.
- Polysaccharides indirectly regulate allergic reactions by modulating immune cells and gut microbiota diversity.
Conclusions:
- Polysaccharides offer a promising avenue for anti-allergy strategies.
- Mechanisms involve direct modification of allergens and indirect immune/microbiota modulation.
- This review provides a theoretical basis for developing anti-allergic dietary components.
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