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Author Reply.

BJOG : an international journal of obstetrics and gynaecology·2026

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Author Spotlight: Enhancing the Offspring Health in Rats with Maternal Exercise During Pregnancy
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Exercise in Pregnancy and Risk of Postpartum Depression: A Randomised Controlled Trial.

Gabriele Saccone1, Giorgia Buonomo1, Alessandra Ammendola1

  • 1Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

BJOG : an International Journal of Obstetrics and Gynaecology
|September 21, 2025
PubMed
Summary

Regular aerobic exercise during pregnancy significantly lowers the risk of postpartum depression in women with low-risk pregnancies. This finding supports exercise as a key preventive strategy for maternal mental health.

Keywords:
antenatal exercisematernal mental healthpostpartum depressionpregnancyrandomised controlled trial

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal Mental Health
  • Preventive Medicine

Background:

  • Postpartum depression (PPD) affects many women, impacting maternal and infant well-being.
  • Identifying effective preventive strategies for PPD is crucial for low-risk pregnancies.

Purpose of the Study:

  • To determine if regular aerobic exercise during pregnancy can reduce the incidence of postpartum depression.
  • To evaluate the impact of antenatal exercise on maternal mental health outcomes in low-risk singleton pregnancies.

Main Methods:

  • A single-centre randomized controlled trial involving 398 women with low-risk singleton pregnancies.
  • Participants were assigned to an aerobic exercise group (3 sessions/week) or a control group until 35 weeks gestation.
  • Primary outcome: Edinburgh Postnatal Depression Scale (EPDS) score ≥12 at 3 months postpartum.

Main Results:

  • Women in the exercise group showed a significantly lower incidence of EPDS scores ≥12 and ≥9 at 3 months postpartum compared to controls.
  • The exercise group also reported lower mean EPDS scores.
  • No significant differences in adverse maternal or perinatal outcomes were observed between groups.

Conclusions:

  • Regular antenatal aerobic exercise is an effective strategy for reducing the risk of postpartum depression in low-risk pregnancies.
  • Aerobic exercise can be recommended as a safe and beneficial intervention for maternal mental health during pregnancy.