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Published on: August 15, 2025
Cannabis polysaccharides (CPs): Extraction methods, structural characteristics, biological activities and
Adil Hussain1, Syed Ali Imran Bokhari2
1Food and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research (PCSIR) Laboratories Complex, Ferozepur Road, Lahore, 54600, Punjab, Pakistan.
Cannabis polysaccharides (CPs) exhibit diverse structures and bioactivities. This review highlights their extraction, characterization, and potential as antioxidants and anti-aging agents, paving the way for pharmaceutical and food applications.
Area of Science:
- Phytochemistry
- Biochemistry
- Pharmacology
Background:
- Cannabis polysaccharides (CPs) are gaining attention for their varied structures and bioactivities.
- Current research focuses on CPs from various cannabis parts, with a majority derived from seeds.
Purpose of the Study:
- To review and consolidate current knowledge on the extraction, characterization, molecular properties, and biofunctional potentials of CPs.
- To explore the impact of extraction methods and structural features on CPs' bioactivities.
Main Methods:
- Literature review of studies on CPs extraction, characterization, and bioactivity.
- Analysis of advanced techniques (HPAEC-PAD, HPSEC, GC-MS, FT-IR) for CPs characterization.
- Examination of molecular weight and monosaccharide composition.
Main Results:
- CP composition varies by plant part, cultivar, and origin.
- Extraction methods significantly influence yield and molecular integrity.
- CPs possess antioxidant and anti-aging activities, modulated by molecular weight and composition, with potential therapeutic applications.
Conclusions:
- CPs display significant structural diversity and biofunctional properties.
- Extraction methods critically affect CPs' yield and bioactivity.
- Further research into underexplored CPs sources and structural-bioactivity relationships is warranted for pharmaceutical and nutraceutical advancements.
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