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Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
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Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

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Fecal microbiota transplantation alleviates chronic cerebral hypoperfusion-induced axonal hypomyelination by

Shao-Hua Su1, Ming Chen2, Da-Ding Lu1

  • 1Department of Neurosurgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.

The Journal of Nutritional Biochemistry
|September 21, 2025
PubMed

Insights

Fecal microbiota transplantation (FMT) may treat chronic cerebral hypoperfusion-induced white matter injury by restoring gut microbiota, improving mitochondrial function, and promoting remyelination. This approach shows promise for central nervous system diseases.

Area of Science:

  • Neuroscience
  • Microbiology
  • Gastroenterology

Background:

  • Fecal microbiota transplantation (FMT) is explored for central nervous system (CNS) diseases.
  • The effect of FMT on chronic cerebral hypoperfusion (CCH)-induced white matter injury (WMI) is unclear.
  • Investigating FMT's role in myelin integrity, axonal survival, and oligodendrogenesis is crucial.

Purpose of the Study:

  • To investigate the potential therapeutic effects and mechanisms of FMT on CCH-induced WMI.
  • To evaluate FMT's impact on myelin integrity, axonal survival, and oligodendrogenesis.
  • To explore the alterations in gut microbiota and associated metabolites following FMT.

Main Methods:

  • Fecal microbiota transplantation (FMT) was administered to a model of chronic cerebral hypoperfusion (CCH).
  • Evaluated white matter injury (WMI) markers, including myelin integrity and axonal survival.
  • Assessed mitochondrial function (electron transport chain activities, ATP production) and oligodendrogenesis.
  • Analyzed gut microbiota composition and fecal/hippocampal metabolite profiles.

Main Results:

  • FMT restored mitochondrial electron transport chain (ETC) activities and enhanced ATP production.
  • FMT mitigated demyelination and axonal degeneration, partly via oligodendrogenesis-dependent remyelination.
  • FMT modulated gut microbiota, increasing specific bacterial groups like Akkermansia muciniphila.
  • FMT altered metabolite profiles, including tryptophan and arginine pathways, linked to gut microbiota changes.

Conclusions:

  • Fecal microbiota transplantation (FMT) demonstrates beneficial effects against demyelination-related white matter injury (WMI) under chronic cerebral hypoperfusion (CCH).
  • FMT improves mitochondrial function and promotes remyelination through oligodendrogenesis.
  • The therapeutic effects are associated with significant alterations in gut microbiota composition and related metabolic pathways.
Keywords:
chronic cerebral hypoperfusiongut microbiotaoligodendrogenesispyruvate metabolismremyelination

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