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Updated: Jan 17, 2026

Defining the Program of Maternal mRNA Translation during In vitro Maturation using a Single Oocyte Reporter Assay
Published on: June 16, 2021
The role of RNA binding proteins in regulating oocyte maturation
1Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China.
Abstract:
Oocyte maturation is a complex and delicate process involving multiple gene expression levels. RNA-binding proteins (RBPs) are pivotal regulators in oocyte maturation and mRNA metabolism through spatiotemporal control of processing, stability, localization, and translational activation. This review synthesizes current knowledge on RBPs-mediated regulatory networks on oocyte maturation and their impacts on oocyte quality and reproductive health. The characteristics of RBPs across species are also discussed, establishing a conceptual framework for developing novel therapeutic strategies to improve female fertility.
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