Long-term survival and operative outcomes of the Bentall procedure for aortic root aneurysm, aortic dissection, and endocarditis
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Published on: December 11, 2017
Christopher Lau1, Alexander Gregg1, Eilon Ram1
1Department of Cardiothoracic Surgery, Weill Cornell Medicine, New York, NY.
Insights
The Bentall procedure offers low operative risk for aortic aneurysms and dissections. While endocarditis increases operative mortality, excellent long-term survival is achievable for all patients.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Aortic Surgery
Background:
- Aortic root pathology requires complex surgical intervention.
- The Bentall procedure is a standard technique for aortic root replacement.
- Outcomes vary based on the underlying diagnosis necessitating the procedure.
Purpose of the Study:
- To evaluate the outcomes of the Bentall procedure for aortic aneurysms, dissections, and endocarditis.
- To compare operative results and long-term survival across different primary diagnoses.
- To identify factors influencing late mortality after aortic root replacement.
Main Methods:
- Retrospective analysis of 1493 patients undergoing Bentall procedures from 1997 to 2023.
- Stratification of patients based on primary diagnosis: aneurysm, dissection, or endocarditis.
- Comparison of operative outcomes, including mortality and complications, and long-term survival.
Main Results:
- Aneurysm repair was most common (92.3%), followed by dissection (5%) and endocarditis (2.7%).
- Endocarditis patients experienced higher rates of acute renal failure and operative mortality.
- Reexploration for bleeding was more frequent in the dissection group.
- Ten-year survival was comparable across all groups (71.8%–83.7%).
- Age, COPD, renal dysfunction, and ejection fraction predicted late mortality, not the primary diagnosis.
Conclusions:
- The Bentall procedure is associated with low operative risk for aneurysms and selected dissections.
- Endocarditis presents higher operative mortality but remains acceptable.
- Patients surviving the initial surgery can expect excellent long-term survival regardless of the primary diagnosis.
Objective:
To assess outcomes after aortic root replacement with Bentall procedure for aortic aneurysm, dissection, and endocarditis.
Methods:
We identified consecutive patients undergoing Bentall procedures from 1997 to 2023, with stratification based on the primary diagnosis. Operative outcomes and long-term survival were compared.
Results:
Of 1493 patients, 1378 (92.3%) underwent surgery for aneurysms, 75 (5%) for dissections, and 40 (2.7%) for endocarditis. The aneurysm group was older (61 years [range, 50-70 years] vs 57 years [range, 47-66.5 years] vs 56 years [range, 49-64 years]; P = .024). Patients with dissection or endocarditis had more preoperative myocardial infarctions (7.4% vs 12% vs 17.5%; P = .026), cerebrovascular accidents (9.6% vs 18.7% vs 45%; P < .001), renal dysfunction (8.3% vs 22.7% vs 45%; P < .001), shock (0.1% vs 10.7% vs 15%; P < .001), and ruptures (0.4% vs 10.7% vs 10%; P < .001). Regarding outcomes, acute renal failure (0.6% vs 1.3% vs 7.5%; P < .001) and operative mortality (0.4% vs 1.3% vs 7.5%; P = .001) were higher for endocarditis. Reexploration for bleeding was highest for dissections (4.1% vs 12% vs 2.5%; P = .004). Ten-year survival was similar between groups (71.8% vs 67% vs 83.7%; P = .94), with mean follow-up 68.2 ± 2.08 months. Multivariable analysis found age (hazard ratio [HR], 1.04; 95% CI, 1.03-1.05; P < .001), chronic obstructive pulmonary disease (HR, 2.12; 95% CI, 1.44-3.11; P < .001), renal dysfunction (HR, 1.97; 95% CI, 1.4-2.78; P < .001), and ejection fraction (HR, 0.97; 95% CI, 0.95-0.98; P < .001) were associated with late mortality but primary diagnosis was not.
Conclusions:
The Bentall procedure can be performed with low operative risk for aneurysms and selected dissections. Endocarditis is associated with higher but acceptable operative mortality. Excellent long-term survival can be expected after surviving initial operative risk.
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