A case report of primary amelanotic malignant melanoma of esophagus

Primary malignant melanoma of the esophagus (PMME) is an extremely rare malignant tumor. Primary amelanotic malignant melanoma is a subtype of PMME which shows no pigmentation under esophagogastroduodenoscopy (EGD). A lack of understanding of this disease makes it susceptible to misdiagnosis and limits its treatment options. Here, we reported a case which misdiagnosed as esophageal polyps with malignant transformation or esophageal cancer when observed on gastroscopy examination, while proved as primary amelanotic malignant melanoma by immunohistochemistry in our department. The aim of this study is to draw the attention of physicians by describing a case of primary amelanotic malignant melanoma and to aid in the diagnosis of this disease in the future.