Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Preclinical Development: Overview

Preclinical Development: Overview

Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Viral variant but not host factors associate with SARS-CoV-2 viral kinetics.

Communications medicine·2026

Same author

Diagonal Investments in Health Systems: PEPFAR's Approach to Sustaining the HIV Response and Enhancing Global Health Security.

The Journal of infectious diseases·2025

Same author

Leveraging Laboratory Information Management Systems to Support HIV and Other Infectious Diseases Testing in PEPFAR-Supported Countries.

The Journal of infectious diseases·2025

Same author

Leveraging PEPFAR- and Global Fund-Supported Laboratory Network for Integrated Disease Testing: Lessons From Integrated HIV, Tuberculosis, and COVID-19 Testing in Nigeria.

The Journal of infectious diseases·2025

Same author

Implementation of All-inclusive Global Purchasing Agreements for Viral Load and Infant Diagnosis in PEPFAR-Supported Countries.

The Journal of infectious diseases·2025

Same author

Sustaining two decades of PEPFAR's response to global HIV/AIDS: mitigating the impact of climate threats.

AIDS (London, England)·2024

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

PEPFAR Laboratory Implementation Strategy as a Component of PEPFAR's 5-Year Strategy.

George Alemnji¹, Ann Sangthong¹, Nicole Espy¹

¹Office of the Global AIDS Coordinator and Health Diplomacy, US Department of State, Washington, District of Columbia, USA.

The Journal of Infectious Diseases

|September 21, 2025

Summary

The President's Emergency Plan for AIDS Relief (PEPFAR) has significantly boosted laboratory capacity for HIV response. These investments now support broader public health, aiding in pandemic preparedness and response.

Keywords:

5-Year Strategy PEPFAR laboratory high quality diagnostics implementation strategy leveraging to support other pandemics

More Related Videos

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Published on: June 17, 2022

Related Experiment Videos

Last Updated: Jul 16, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics

Published on: June 17, 2022

Area of Science:

Global Health Security
Laboratory Systems Strengthening
Infectious Disease Epidemiology

Background:

Past investments by the U.S. President's Emergency Plan for AIDS Relief (PEPFAR) have substantially improved clinical and public health laboratory capacity globally.
These laboratory systems are crucial for broader health system functioning, including diagnostics for various diseases and outbreak response.

Purpose of the Study:

To outline how PEPFAR's strategic approaches can sustain HIV/AIDS gains.
To guide integrated support for national public health systems.
To strengthen local capacity for future pandemic preparedness and response.

Main Methods:

Leveraging existing PEPFAR-supported laboratory infrastructure.
Collaborating with national governments and global health stakeholders.
Implementing PEPFAR's 5 × 3 strategic approaches.

Main Results:

PEPFAR laboratory investments have demonstrably improved diagnostic capabilities for HIV and tuberculosis.
Existing PEPFAR laboratory systems were successfully adapted for coronavirus disease 2019 and mpox outbreak response.
Sustained focus on HIV and tuberculosis gains while enhancing pandemic preparedness.

Conclusions:

PEPFAR's laboratory strengthening efforts have built resilient health systems capable of addressing multiple health threats.
Integrated approaches are key to sustaining HIV/AIDS progress and bolstering pandemic preparedness.
Continued collaboration is essential for national health system strengthening and global health security.