Gold-Catalyzed Arylative Meyer-Schuster Rearrangement of Aryl Iodides to α-Arylated Enones
1School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China.
Abstract:
Enones serve as versatile scaffolds in synthetic chemistry, enabling diverse transformations while exhibiting biologically relevant properties crucial for drug development. Herein, we report a ligand-enabled gold-catalyzed arylative Meyer-Schuster rearrangement employing readily available and stable propargylic acetates and aryl iodides under mild conditions. This method efficiently delivers α-arylated enones with a broad substrate scope and air-tolerant conditions, while avoiding the need for strong external oxidants or photocatalytic activation of aryl diazonium salts.
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