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Change in Cognition Following Ischaemic Stroke.

Wenci Yan1,2, Terence Quinn3, Alex McConnachie4

  • 1Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, China.

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|September 22, 2025
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Summary
This summary is machine-generated.

Cognition after ischemic stroke is dynamic. Factors like brain volume and vascular health influence cognitive changes over two years, impacting rehabilitation strategies.

Keywords:
cognitive impairmentcognitive trajectorypost‐stroke cognitionrisk factorstroke

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Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Research

Background:

  • Cognitive decline is a common outcome after ischemic stroke.
  • Understanding the trajectory of cognitive changes and associated factors is crucial for patient care.

Purpose of the Study:

  • To explore cognitive changes over two years post-ischemic stroke.
  • To identify factors associated with cognitive improvement and decline.

Main Methods:

  • Analysis of data from the XILO-FIST study involving 360 participants.
  • Cognitive function assessed using the Montreal Cognitive Assessment (MoCA) at baseline, year 1, and year 2.
  • Statistical analysis including univariable and multiple logistic regression.

Main Results:

  • Seventy-seven participants showed cognitive improvement, while 84 experienced decline by year two.
  • Cognitive improvement linked to smaller brain volume, lower albumin, smoking, and white-matter hyperintensity.
  • Cognitive decline associated with peripheral arterial disease, higher cholesterol, small-vessel stroke, and white-matter hyperintensity.

Conclusions:

  • Cognitive trajectories post-stroke are variable and influenced by brain reserve and vascular risk factors.
  • These findings highlight the complexity of post-stroke cognitive changes.
  • Implications for tailored cognitive rehabilitation and early detection of impairment.