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Change in Cognition Following Ischaemic Stroke
Wenci Yan1,2, Terence Quinn3, Alex McConnachie4
1Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, China.
Annals of Clinical and Translational Neurology
|September 22, 2025
Summary
Cognition after ischemic stroke is dynamic. Factors like brain volume and vascular health influence cognitive changes over two years, impacting rehabilitation strategies.
Area of Science:
- Neurology
- Neuroscience
- Clinical Research
Background:
- Cognitive decline is a common outcome after ischemic stroke.
- Understanding the trajectory of cognitive changes and associated factors is crucial for patient care.
Purpose of the Study:
- To explore cognitive changes over two years post-ischemic stroke.
- To identify factors associated with cognitive improvement and decline.
Main Methods:
- Analysis of data from the XILO-FIST study involving 360 participants.
- Cognitive function assessed using the Montreal Cognitive Assessment (MoCA) at baseline, year 1, and year 2.
- Statistical analysis including univariable and multiple logistic regression.
Main Results:
- Seventy-seven participants showed cognitive improvement, while 84 experienced decline by year two.
- Cognitive improvement linked to smaller brain volume, lower albumin, smoking, and white-matter hyperintensity.
- Cognitive decline associated with peripheral arterial disease, higher cholesterol, small-vessel stroke, and white-matter hyperintensity.
Conclusions:
- Cognitive trajectories post-stroke are variable and influenced by brain reserve and vascular risk factors.
- These findings highlight the complexity of post-stroke cognitive changes.
- Implications for tailored cognitive rehabilitation and early detection of impairment.
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