Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Types02:20

Blood Types

18.1K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
18.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tissue Screening and Diagnosis of Transthyretin Amyloid Cardiomyopathy.

Reviews in cardiovascular medicine·2026
Same author

Real-World Outcomes with BCMA- and GPRC5D-Targeting Bispecific Antibodies in Plasma Cell Leukemia.

Blood advances·2026
Same author

Demystifying Arrhythmia Surveillance in Cardiac Amyloidosis With EXCALIBUR.

Journal of the American College of Cardiology·2026
Same author

Breaking the Anchor: Overcoming Diagnostic Bias in Overlapping Cardiac Pathologies.

Circulation·2026
Same author

Fully human BCMA CAR-T therapy in multiple myeloma: lessons from long-term follow-up.

Translational cancer research·2026
Same author

Dexamethasone for Management of Cytokine Release Syndrome Associated With Talquetamab in Patients With Relapsed/Refractory Multiple Myeloma.

American journal of hematology·2026

Related Experiment Video

Updated: May 3, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.1K

Molecular Expression Differences in Specific Blood Mononuclear Cell-Types Identify Patients With AL Amyloidosis.

David Kaplan1,2, Eric Christian1, Jason Valent3

  • 1CellPrint Biotechnology, Cleveland, Ohio, USA.

Journal of Cellular and Molecular Medicine
|September 22, 2025
PubMed
Summary
This summary is machine-generated.

Diagnosing AL amyloidosis is difficult, but new blood biomarkers from specific immune cells show promise. These biomarkers, found in CD4+ T cells and monocytes, could improve diagnosis and monitoring for AL amyloidosis patients.

Keywords:
AL amyloidosisblood‐based biomarkercell‐specific molecular expressiondiagnostic assaymyeloma

More Related Videos

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K
Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay
11:27

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay

Published on: February 7, 2025

1000

Related Experiment Videos

Last Updated: May 3, 2026

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.1K
Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

8.1K
Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay
11:27

Prediction of Red Blood Cell Antibody Significance Using the Monocyte-Macrophage Assay

Published on: February 7, 2025

1000

Area of Science:

  • Immunology
  • Biochemistry
  • Hematology

Background:

  • AL amyloidosis diagnosis is challenging due to systemic and varied symptoms.
  • Current blood biomarkers for AL amyloidosis lack optimal diagnostic and monitoring capabilities.

Purpose of the Study:

  • To investigate mononuclear cell-specific molecular expression for novel blood-based biomarkers in AL amyloidosis.
  • To identify diagnostic and monitoring biomarkers for AL amyloidosis using flow cytometry.

Main Methods:

  • Assessed expression levels of 20 analytes in peripheral blood monocytes and CD4+ T cells from AL amyloidosis and myeloma patients.
  • Utilized enhanced flow cytometric analysis and logistic regression with ROC analysis for biomarker discovery.

Main Results:

  • Identified significant expression differences for brain-derived neurotrophic factor (BDNF) and phospho-TBK1 in CD4+ T cells, and phospho-GSK3β in monocytes.
  • BDNF in CD4+ T cells and heme oxygenase 1 in monocytes distinguished between myeloma and AL amyloidosis patients (AUC=0.75).
  • Observed distinct intermolecular associations, suggesting specific pathogenetic pathways in AL amyloidosis.

Conclusions:

  • Mononuclear cell-specific molecular expression holds potential for developing diagnostic assays and biomarkers for AL amyloidosis.
  • These findings may lead to improved diagnostic tools and patient monitoring strategies for AL amyloidosis.