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A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells

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Case Report: Three cases with allogeneic CIK therapy against solid tumors.

Yanfei Li¹, Xianwu Wang¹, Lili Yao¹

¹Cell Therapy Research Center, Xiamen Humanity Hospital, Xiamen, China.

Frontiers in Immunology

|September 22, 2025

Summary

Cytokine-induced killer (CIK) cell therapy offers a safe and effective alternative for solid tumor patients who cannot benefit from traditional chemotherapy. This immunotherapy shows promise in managing difficult-to-treat cancers and preventing recurrence.

Area of Science:

Keywords:

CIK carcinoma case report cell culture cell therapy

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Oncology
Immunotherapy
Cellular Therapy

Background:

Adjuvant chemotherapy is often ineffective for malignant solid tumors due to limited treatment options for certain cancers (e.g., renal, liver) and patient-specific factors like age, comorbidities, and adverse reactions.
While targeted therapies and immune checkpoint inhibitors have advanced cancer treatment, their use is constrained by genetic testing requirements, drug resistance, and significant side effects.
Cytokine-induced killer (CIK) cell therapy, involving the infusion of activated T cells, presents a safer alternative with a favorable side effect profile, showing potential in eliminating micrometastases and preventing tumor recurrence.