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Published on: March 28, 2025
Impact of oral pathogens on inflammatory mediator expression in oral cells
Pratik Sanjay Hodar1, Mitesh Shah2, Yihan Fu3
1Department of Prosthodontics & Crown and Bridge, Shri Yashwantrao Chavan Memorial Medical & Rural Development Foundation's Dental College & Hospital, Vadgaon Gupta Road, Ahmednagar - 414003, Maharashtra, India.
Abstract:
Oral pathogens such as P. gingivalis, F. nucleatum and A. actinomycetemcomitans significantly elevate cytokine levels in oral epithelial cells. qRT - PCR analysis showed P. gingivalis induced a 4.2-fold increase in IL-1β, 3.8-fold in TNF-α, and 3.5-fold in IL-6 after 24 hours. The other pathogens also triggered a 2.4 to 3.6-fold cytokine rise (p < 0.05). This indicates their role in initiating oral inflammation through pro-inflammatory cytokine activation. Targeted microbial therapy may offer benefits in managing such conditions.
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