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Updated: Jan 17, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
Prospective cohort study on vitamin D deficiency and its association with multiple sclerosis relapses
Lokesh Kumar Gurram1, Rohan Hassan Chandrashekara2, Ashok Nimmakanty Ramadas3
1Department of Internal Medicine, University Hospital of Wales (UHW), Heath Park Way, Cardiff, CF14 4XW, UK.
None:
Vitamin D deficiency has been related to the pathogenesis and clinical course of multiple sclerosis (MS), especially with relapse frequency. Hence, a prospective cohort study explored the relationship between serum vitamin D level and MS relapses in 120 patients in a two-year follow-up. Baseline and follow-up serum 25-hydroxyvitamin D were measured and relapse events registered and examined. The result indicated a strong negative correlation between the frequency of relapse and vitamin D (p < 0.01), such that patients with low levels of vitamin (<20 ng/mL) had higher frequencies of relapse.
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