Fetal loss in women exposed to cigarette smoke in-utero
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View abstract on PubMed
Summary
This summary is machine-generated.Maternal smoking during pregnancy increases fetal loss risk. This risk is amplified when the individual also smokes, highlighting a combined effect on pregnancy outcomes.
Area Of Science
- Reproductive Health
- Perinatal Epidemiology
- Toxicology
Background
- Animal studies suggest in-utero smoke exposure causes meiotic errors.
- Human epidemiological studies on in-utero smoke exposure and fetal loss are inconclusive and lack control for other smoke exposures.
Purpose Of The Study
- To investigate the association between cigarette smoke exposure in-utero and fetal loss risk.
- To differentiate the effects of in-utero smoke exposure from active or second-hand smoking.
Main Methods
- Utilized data from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (n=15,445).
- Assessed fetal loss (miscarriage or stillbirth) and maternal smoking during pregnancy via obstetric history and questionnaires.
- Performed logistic regression, adjusting for confounders and stratifying by smoke exposure.
Main Results
- In 7033 women with known in-utero smoke exposure and fetal loss status, 2012 were exposed in-utero.
- Among women exposed in-utero, 34.1% experienced fetal loss.
- Ever smokers exposed in-utero (n=1182) had significantly higher odds of fetal loss (aOR: 1.26; 95% CI: 1.08, 1.47) compared to ever smokers not exposed in-utero (n=2354).
Conclusions
- In-utero smoke exposure is linked to increased fetal loss odds.
- This association is significantly compounded by the participant's own active smoking during pregnancy.
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