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Multimorbidity of hidradenitis suppurativa: a cross-sectional population-based study of its associated comorbidities
Manuel Almenara-Blasco1, Tamara Gracia-Cazaña1, Beatriz Poblador-Plou2,3
1Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Insights
Hidradenitis suppurativa (HS) is a chronic skin condition linked to numerous comorbidities, including metabolic, neuropsychiatric, and infectious diseases. This study highlights the significant burden of multimorbidity in HS patients, emphasizing the need for integrated care.
Area of Science:
- Dermatology
- Epidemiology
- Public Health
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with substantial physical and psychological impacts.
- Previous studies have described individual comorbidities of HS, but a comprehensive analysis in a large population is lacking.
Purpose of the Study:
- To determine the prevalence of hidradenitis suppurativa (HS) in a large population.
- To describe the comorbidities associated with HS.
- To analyze which diseases are more likely to occur in individuals with HS.
Main Methods:
- A retrospective, cross-sectional observational study using electronic health records from the EpiChron Cohort (Aragón, Spain).
- Included 1,003 individuals diagnosed with HS in 2019.
- Logistic regression models were used to assess the association between HS and comorbidities (prevalence ≥1%), adjusting for age, sex, and other comorbidities.
Main Results:
- The prevalence of HS was 0.10%, higher in women (0.12%) than men (0.08%).
- The most frequent comorbidities were lipid metabolism disorders (27.8%), hypertension (19.7%), and anxiety disorders (18.7%).
- Conditions significantly associated with HS included skin infections (OR 3.32), white blood cell diseases (OR 2.11), and schizophrenia (OR 2.17).
Conclusions:
- HS is associated with a high burden of multimorbidity across metabolic, neuropsychiatric, musculoskeletal, and infectious categories.
- Findings emphasize the necessity for integrated, multidisciplinary management strategies for HS patients.
- Further longitudinal research is recommended to investigate causal links and enhance clinical outcomes.
Background:
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disorder associated with significant physical and psychological burden. While individual comorbidities have been described in prior studies, a comprehensive analysis of all chronic conditions associated with HS in a large population-based cohort is lacking.
Objectives:
To determine the prevalence of hidradenitis suppurativa in a large-scale, population-based study, to describe its comorbidities, and to analyze which diseases are associated with the presence of hidradenitis.
Methods:
Retrospective cross-sectional observational study based on the clinical information contained in the electronic health records from the individuals of the EpiChron Cohort (Aragón, Spain) with a diagnosis of hidradenitis suppurativa (1,003 individuals from all ages and sexes) in 2019. We analyzed the prevalence of chronic comorbidities and used logistic regression models adjusted for age, sex and comorbidities to calculate the likelihood of occurrence of each of the comorbidities with a prevalence ≥1% based on the presence of hidradenitis. We used a cut-off point for statistical significance of p-value < 0.05.
Results:
The prevalence of hidradenitis suppurativa was 0.10%, and it was more prevalent in women (0.12% vs. 0.08%). The most frequent chronic comorbidities were disorders of lipid metabolism (27.8%), hypertension (19.7%), and anxiety disorders (18.7%). The conditions most associated with hidradenitis were (odds ratio; 95% confidence interval) skin and subcutaneous tissue infections (3.32; 2.56-4.30), diseases of white blood cells (2.11; 1.44-3.07), and schizophrenia and other psychotic disorders (2.17; 1.16-4.06), among others.
Conclusion:
HS is associated with a high burden of multimorbidity, encompassing metabolic, neuropsychiatric, musculoskeletal, and infectious conditions. These findings underscore the need for integrated and multidisciplinary management strategies. Further longitudinal research is warranted to explore causal relationships and improve clinical outcomes.
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