JoVE - Journal of Visualized Experiments
JoVE Visualize
Contact Us

Past Marks: A Case Report of Basal Cell Carcinoma Induced by Arsenic Exposure

  • 0Planalto Family Health Unit, Lezíria Local Health Unit, Santarém, PRT.
Cureus +

|

September 22, 2025

|

September 22, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Chronic arsenic exposure, historically from treatments like Fowler's solution, is linked to basal cell carcinoma (BCC). This case underscores the need for lifelong surveillance in patients with significant arsenic exposure due to increased skin cancer risk.

Area Of Science

  • Dermatology
  • Toxicology
  • Oncology

Background

  • Basal cell carcinoma (BCC) is a prevalent skin cancer globally.
  • Chronic arsenic exposure is a suspected etiological factor for BCC.
  • Individual susceptibility to arsenic-induced BCC varies due to genetic and environmental factors.

Purpose Of The Study

  • To present a case study of recurrent BCC in a patient with a history of prolonged Fowler's solution use.
  • To highlight arsenic as a plausible contributing factor in the development of cutaneous neoplasms.
  • To emphasize the importance of detailed medical history regarding toxic agent exposure.

Main Methods

  • Case report of a 69-year-old patient with a history of psoriasis treated with Fowler's solution.
  • Documentation of recurrent BCC development and subsequent treatments.
  • Assessment of historical arsenic exposure as a potential causative agent.

Main Results

  • The patient developed recurrent basal cell carcinoma.
  • Prolonged use of Fowler's solution (an arsenic-based treatment) was identified as a significant risk factor.
  • Continuous surveillance and treatment were necessary for the patient's condition.

Conclusions

  • Long-term arsenic exposure, particularly from historical medicinal solutions, can contribute to the development of skin cancer.
  • Patients with documented arsenic exposure exceeding six months require lifelong medical surveillance.
  • Identifying past exposure to toxic agents is crucial for managing and preventing arsenic-related health conditions, including skin cancer.

Keywords: