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Vaccinated Toddler With 15B/15C Serotype Switch Pneumococcal Meningitis
Richard Kevorkian1, Milene T Williams2, Cory M Mcfadden3
1Infectious Disease Lab, Landstuhl Regional Medical Center, Landstuhl, DEU.
Cureus
|September 22, 2025
Summary
A fatal case of pneumococcal meningitis occurred in a fully vaccinated child, caused by emerging serotypes not covered by PCV13. PCV20 may offer broader protection against invasive pneumococcal disease.
Area of Science:
- Pediatrics
- Infectious Diseases
- Microbiology
Background:
- Streptococcus pneumoniae (S. pneumoniae) is a major cause of childhood pneumonia and meningitis globally.
- Pneumococcal conjugate vaccines (PCVs) have reduced disease burden, but challenges remain with emerging serotypes.
- Invasive pneumococcal disease (IPD) continues to affect young children despite vaccination efforts.
Keywords:
invasive pneumococcal diseasemeningitispcv13pcv20pediatric vaccinestreptococcus pneumoniaevaccine coverageMore Related Videos
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