Related Experiment Video
Updated: Jan 17, 2026
07:17
Single Port Donor Nephrectomy
Published on: March 12, 2011
52.3K
Changes in Kidney Function Following Living Donor Nephrectomy: A Retrospective, Single-Center, Descriptive Study.
Christy Rajeevkumar Ratnakumar1,2, Mohamed Nazar Abdul Latiff1, Gayathri Rajeevkumar3
1Nephrology, National Hospital of Sri Lanka, Colombo, LKA.
Cureus
|September 22, 2025
Summary
Kidney donation shows no sustained drop in kidney function over time, though age impacts GFR. Long-term donor outcomes are generally safe, with no significant risk of proteinuria post-nephrectomy.
Area of Science:
- Nephrology
- Transplant Surgery
- Public Health
Background:
- Kidney transplantation is optimal for end-stage renal disease.
- Donor outcomes post-nephrectomy require further investigation.
- Long-term complications in kidney donors are not fully understood.
Purpose of the Study:
- Assess changes in kidney function after donor nephrectomy.
- Identify comorbidities associated with kidney donation.
- Evaluate long-term donor health in a Sri Lankan cohort.
Main Methods:
- Descriptive retrospective study.
- 102 donors undergoing nephrectomy since 2005.
- Analysis of Glomerular Filtration Rate (GFR), urine protein creatinine ratio (UPCR), and serum creatinine (SCr).
Main Results:
- GFR showed an initial insignificant drop post-surgery, with no sustained decline.
- Serum creatinine and UPCR changes were statistically insignificant.
- Older age was significantly associated with a decrease in GFR post-nephrectomy.
Conclusions:
- Kidney donation does not lead to a sustained GFR decline.
- No significant risk of developing proteinuria was observed.
- Older age is a risk factor for reduced GFR after donor nephrectomy.
Related Concept Videos
01:28Kidney Transplant I: Introduction
345
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
345
01:26Kidney Transplant II: Surgical Procedure
320
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
320
01:16Kidney Transplant III: Nursing Management
318
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
318
01:29Acute Kidney Injury III: Clinical Manifestations
827
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
827
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
271
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
271
01:45Kidney Structure
74.9K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
74.9K