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Immune Thrombocytopenia Coexisting With Celiac Disease and Liver Dysfunction: A Case Report of Multifactorial
Hafiz Muhammad Faizan Mughal1, Muhammad J Khan2, Abdul Rehman Khalil Shaikh3
1Internal Medicine, Khawaja Muhammad Safdar Medical College, Sialkot, PAK.
Insights
Celiac disease (CD) can present with rare immune comorbidities like immune thrombocytopenia (ITP) and autoimmune hepatitis. Early diagnosis and treatment with a gluten-free diet and immunosuppressants are crucial for managing these complex conditions.
Area of Science:
- Gastroenterology
- Immunology
- Hepatology
Background:
- Celiac disease (CD) is a chronic immune disorder affecting the small intestine.
- CD is linked to immune abnormalities, including immune thrombocytopenia (ITP) and liver diseases.
- Simultaneous diagnosis of CD with ITP and liver issues is uncommon and diagnostically challenging.
Abstract:
Celiac disease (CD) is a chronic disorder that influences the immune system and is also associated with abnormalities in blood and liver functions. Reports have indicated the presence of immune thrombocytopenia (ITP) and liver diseases in CD, individually, but the simultaneous occurrence of both is rare and therefore difficult to diagnose. Here, we described the case of a 49-year-old woman who had thrombocytopenia and elevated liver enzymes, but showed no gastrointestinal symptoms. However, a complete assessment led to the simultaneous diagnosis of CD, ITP, and autoimmune hepatitis. Treatment with a gluten-free diet and immunosuppressive therapy helped in both restoring the platelet counts and normalizing liver enzymes. The case illustrated that recognizing unusual symptoms in CD is important and it requires the involvement of several experts if immune comorbidities are found.
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