Related Experiment Video

Updated: May 5, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
19:57

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings

Published on: March 30, 2014

19.2K

Addressing Multidrug-Resistant Organisms (MDROs) Through Antimicrobial Stewardship in Nigeria: A Review of

Daniel O Umoru1, Chidinma V Muoghalu2, Rebecca A Omachonu3

  • 1Pharmacy, National Hospital Abuja, Abuja, NGA.

Cureus
|September 22, 2025
PubMed

Insights

Multidrug-resistant organisms (MDROs) pose a significant threat in Nigeria. Strengthening antimicrobial stewardship programs (ASPs) through policy, infrastructure, and education is crucial to combat resistance and protect public health.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Healthcare Management

Background:

  • Multidrug-resistant organisms (MDROs) represent a critical and escalating public health concern in Nigeria.
  • Inappropriate antibiotic use, insufficient surveillance, and underdeveloped healthcare infrastructure exacerbate the MDRO crisis.
  • Antimicrobial stewardship programs (ASPs) are essential interventions to optimize antibiotic use and mitigate resistance.

Purpose of the Study:

  • To conduct a scoping review of evidence on the implementation of ASPs in Nigeria.
  • To identify challenges, opportunities, and effective strategies for establishing and enhancing ASPs in the Nigerian context.
  • To synthesize findings from studies published between 2018 and 2025.

Main Methods:

  • A comprehensive scoping review methodology was employed to synthesize existing literature.
  • Evidence from studies published within a defined timeframe (2018-2025) was systematically examined.
  • Data visualization techniques were used to present resistance trends, ASP frameworks, and implementation challenges.

Main Results:

  • Key implementation challenges identified include inadequate diagnostic capabilities, weak regulatory enforcement, and resource limitations.
  • Significant opportunities for improvement involve technological integration, international collaborations, and the adoption of a One Health approach.
  • Proposed strategies encompass enhancing diagnostic stewardship, investing in laboratory infrastructure, enforcing prescribing policies, and integrating AMR education.

Conclusions:

  • The growing burden of MDROs in Nigeria necessitates immediate, coordinated interventions.
  • Strengthening antimicrobial stewardship is paramount, requiring robust policy enforcement, infrastructure development, and educational initiatives.
  • Effective ASP implementation is vital for curbing antimicrobial resistance and safeguarding national public health.
Keywords:
antibiotic resistanceantimicrobial resistanceantimicrobial stewardshipinfectious diseasemulti-drug resistant organism (mdro)nigeriaone healthsurveillance

More Related Videos

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

11.6K
Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance06:42

Author Spotlight: Exploring the Antibacterial Effects of Zinc Oxide Nanoparticles in Overcoming Antibiotic Resistance

Published on: September 27, 2024

3.0K

Related Concept Videos

Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.6K
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
6.8K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
543
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
253
Urinary Tract Infection IV: Nursing Management01:17

Urinary Tract Infection IV: Nursing Management

In managing urinary tract infections (UTIs) in nursing, a comprehensive assessment is essential. Begin by gathering subjective data, such as the patient’s complaints of dysuria (painful urination), urinary frequency, urgency, suprapubic pain, and any lower abdominal discomfort. This information can be complemented by questions regarding previous UTIs, sexual activity, and personal hygiene practices, which can provide insight into risk factors. Objective assessment should focus on signs...
438
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
1.3K