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Enterocin Ent7420 - a potential postbiotic additive: effect on growth, immune response and gut health in
Monika Pogány Simonová1, Ľubica Chrastinová2, Jana Ščerbová1
1Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal Physiology, Košice, Slovakia.
Abstract:
Increasing occurrence of methicillin-resistant (MR) staphylococci in humans and animals leads to special attention because of their difficult treatment and zoonotic character. Therefore, novel natural antimicrobial compounds directed against antibiotic-resistant bacteria are requested to overcome this problem. Currently, bacteriocins/enterocins (proteinaceous substances with antimicrobial activity produced by several lactic acid bacteria/enterococci) present a new promising strategy, both in prevention and treatment. The aim of this work was to evaluate the effect of Enterocin Ent7420 against the MR Staphylococcus epidermidis SEP3/Tr2a (MRSE) strain in a rabbit (food animal) model, testing its influence and protective effect on body weight (BW), feed conversion ratio (FCR), phagocytic activity (PA), serum glutathione-peroxidase (GPx) enzyme activity, and jejunal morphology (JM). Ninety-six weaned broiler rabbits were divided into experimental groups S (MRSE strain; to simulate the pathogen attack), E (Ent7420), E + S (Ent7420 + MRSE), and control group (C; without substances). Higher BW and lower FCR (NS) were recorded during Ent7420 application. Decreased JM values (p < 0.05) reflect the MRSE strain's damaging effect on the rabbit organism. Improved parameters of GPx and JM during substance combination suggest that Ent7420 may mitigate staphylococcal pathogenesis, warranting further investigation. These results suggest not only promising preventive use of Ent7420 to improve the growth and immunity of rabbits but also its protective effect against possible staphylococcal (MRSE) infections in rabbit breeding.
Insights
Enterocin Ent7420 shows promise in combating methicillin-resistant Staphylococcus epidermidis (MRSE) infections in rabbits. This natural antimicrobial improved rabbit growth and immunity, suggesting potential for preventing staphylococcal diseases in animal agriculture.
Area of Science:
- Veterinary Microbiology
- Animal Nutrition
- Food Safety
Background:
- Antibiotic resistance in staphylococci poses a significant threat due to difficult treatments and zoonotic potential.
- Novel natural antimicrobials are needed to combat antibiotic-resistant bacteria.
- Bacteriocins, like Enterocin Ent7420, offer a promising strategy against resistant pathogens.
Purpose of the Study:
- To evaluate the efficacy of Enterocin Ent7420 against methicillin-resistant Staphylococcus epidermidis (MRSE) in a rabbit model.
- To assess the protective effects of Enterocin Ent7420 on rabbit growth, immunity, and gut health.
Main Methods:
- Ninety-six broiler rabbits were divided into four groups: MRSE infection, Enterocin Ent7420 administration, combined treatment, and control.
- Key parameters monitored included body weight (BW), feed conversion ratio (FCR), phagocytic activity (PA), serum glutathione-peroxidase (GPx) activity, and jejunal morphology (JM).
Main Results:
- Enterocin Ent7420 administration resulted in higher BW and improved FCR.
- MRSE infection led to decreased jejunal morphology (JM) values, indicating pathological damage.
- Combined treatment with Enterocin Ent7420 and MRSE showed improved GPx activity and JM, suggesting mitigation of staphylococcal pathogenesis.
Conclusions:
- Enterocin Ent7420 demonstrates potential as a preventive agent to enhance rabbit growth and immunity.
- The study suggests a protective role for Enterocin Ent7420 against MRSE infections in rabbit farming.
- Further research is warranted to explore the full potential of Enterocin Ent7420 in animal health and disease prevention.
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