Polydatin: A natural compound with multifaceted anticancer properties.

Area of Science:

• Oncology and Pharmacology
• Natural Product Chemistry

Background:

• Cancer remains a leading global health challenge, necessitating research into novel therapeutic agents.
• Polydatin (PD), a natural stilbenoid, possesses diverse biological activities, including potent anticancer effects.

Purpose of the Study:

• To comprehensively review the anticancer attributes of polydatin across various cancer types.
• To elucidate polydatin's impact on cancer hallmarks and its mechanisms of action.
• To explore polydatin's synergistic potential with other anticancer drugs.

Main Methods:

• Systematic literature review of research articles, clinical trials, and reviews.
• Searches conducted on PubMed, ScienceDirect, and Google Scholar using specific cancer type keywords.
• Critical evaluation of selected studies to extract insights on mechanisms and drug interactions.

Main Results:

• Polydatin demonstrates multifaceted anticancer effects, impacting proliferation, migration, and metastasis.
• It influences key cancer hallmarks and targets crucial pathways involved in cancer progression.
• Polydatin exhibits potential for synergistic effects when combined with other anticancer agents.

Conclusions:

• Polydatin shows significant promise as a therapeutic agent in cancer treatment and prevention.
• Its ability to target various cancer facets and address treatment resistance is noteworthy.
• Further research into mechanism-based strategies involving polydatin could advance novel cancer therapies.