Related Experiment Video

Updated: Jan 17, 2026

Use of a Hanging-weight System for Isolated Renal Artery Occlusion
07:54

Use of a Hanging-weight System for Isolated Renal Artery Occlusion

Published on: July 19, 2011

16.4K

The Mortality Risk of Acute Kidney Injury Stage 1A and 1B in Cirrhosis: A Systematic Review and Meta-Analysis

Yue-Meng Wan1, Hua-Mei Wu1, Yu-Hua Li1

  • 1Gastroenterology Department II, The 2nd Affiliated Hospital of Kunming Medical University, Kunming City, Yunnan Province, 650101, China.

Journal of Clinical and Experimental Hepatology
|September 22, 2025
PubMed

Insights

Acute kidney injury (AKI) in cirrhosis, stages 1A and 1B, affects about one in six patients. Both stages significantly increase mortality risk in cirrhotic patients compared to no AKI.

Area of Science:

  • Nephrology
  • Gastroenterology
  • Critical Care Medicine

Background:

  • Cirrhosis is a significant risk factor for acute kidney injury (AKI).
  • AKI in cirrhosis is categorized into stages, including 1A and 1B, with varying reported prevalence.
  • The differential mortality risk associated with AKI stages 1A and 1B in cirrhotic patients remains incompletely understood.

Purpose of the Study:

  • To systematically review and meta-analyze the prevalence of AKI stages 1A and 1B in patients with cirrhosis.
  • To quantify and compare the mortality risks associated with AKI stages 1A, 1B, and non-AKI (NAKI) in cirrhotic patients.

Main Methods:

  • A comprehensive literature search was conducted across major databases (PubMed, Cochrane, EMBASE, Scopus, CNKI).
  • Search terms focused on acute kidney injury, cirrhosis, and mortality.
  • A meta-analysis was performed to pool prevalence and mortality odds ratios for AKI stages 1A and 1B.

Main Results:

  • Eleven studies involving 2647 patients with AKI stage 1A, 3052 with stage 1B, and 1395 without AKI were included.
  • Pooled prevalence for AKI stage 1A was 16.3% and for stage 1B was 15.7%.
  • Compared to NAKI, AKI stage 1A increased mortality risk by approximately 2-fold (OR: 1.98), and stage 1B by 4.8-fold (OR: 4.79). AKI stage 1B further increased mortality risk by 1.6-fold compared to stage 1A.

Conclusions:

  • AKI stages 1A and 1B are prevalent in approximately one in six cirrhotic patients.
  • Both AKI stage 1A and 1B are independently associated with significantly increased mortality in cirrhotic patients.
  • AKI stage 1B confers a substantially higher mortality risk than AKI stage 1A.
Abstract

Keywords:
acute kidney injurycirrhosismortality riskstage 1Astage 1B

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.9K
Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

40.8K

Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
581
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
271
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
903
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
827
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
297
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
344