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Olive Oil Polyphenols: A Promising Approach for Cancer Prevention and Therapy

Muhammad Junaid Anwar1, Muhammad Hammad Anwar2, Muhammad Imran3

  • 1Department of Food Science and Technology, Faculty of Food Science and Nutrition Bahauddin Zakariya University Multan Pakistan.

Food Science & Nutrition
|September 22, 2025
PubMed

Insights

Olive oil and its compounds show significant potential in cancer treatment by targeting specific cancer markers and modulating key pathways. Further research is needed to determine optimal dosages for therapeutic use.

Area of Science:

  • Oncology
  • Nutraceuticals
  • Molecular Biology

Background:

  • Cancer is a leading global cause of death, driving research into natural treatment strategies.
  • Olive oil (OO) and its phytochemicals, oleuropein and hydroxytyrosol (HT), are gaining attention for their potential anti-cancer properties.

Purpose of the Study:

  • To review the antioxidant potential of olive oil and its components.
  • To summarize pathways and markers involved in cancer prevention and treatment using olive oil.

Main Methods:

  • Systematic literature search of Google Scholar, PubMed, and Web of Science.
  • Analysis of studies investigating olive oil's effects on cancer markers and pathways.

Main Results:

  • Identified cancer-specific markers (e.g., 27-OHC, HER2, iNOS, GLUT4, PD-L1) modulated by olive oil.
  • Olive oil influences tumor suppressor genes, oncogenes, and signaling pathways (PI3K/AKT/mTOR, Wnt/β-catenin, MAPK).

Conclusions:

  • Olive oil and its phytochemicals demonstrate significant potential for cancer prevention and treatment.
  • Further research is required to establish precise therapeutic dosages for olive oil and its constituents.
Keywords:
STAT3hydroxytyrosollung canceroleuropein breast cancerolive oilpolyphenols

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