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IL17RA and IL21R polymorphisms influence type 1 diabetes predisposition and autoimmune phenotypes

Cintia Semzezem1, Karla Fabiana Brasil Gomes1, Aritania Sousa Santos1

  • 1Laboratório de Carboidratos e Radioimunoensaios (LIM-18) do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Frontiers in Endocrinology
|September 22, 2025
PubMed
Summary

Polymorphisms in interleukin receptors IL-17RA and IL-21R influence type 1 diabetes (T1D) risk and autoantibody presence. Specific variants are linked to increased T1D susceptibility and altered autoantibody profiles in patients.

Keywords:
IL-17RAIL-21Rextra-pancreatic autoantibodiesislet autoantibodiestype 1 diabetes

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