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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Re-evaluating basophil count as a hematological indicator for bone density: a subgroup analysis from an East Asian

Yu-Li Wang1,2, Shu-Wei Huang3, Jun-Jie Hong4

  • 1Department of Surgery, Hualien Armed Force General Hospital, Hualien, Taiwan.

Frontiers in Endocrinology
|September 22, 2025
PubMed
Summary

Peripheral blood basophil count is not a reliable biomarker for bone mineral density (BMD) in adults. However, elevated BMI may reveal a potential link, and alanine aminotransferase (GPT) shows promise for assessing bone health.

Keywords:
East Asian populationalanine aminotransferase (GPT)basophil countbone mineral density (BMD)hematologic biomarkerlow-cost screening toolmetabolic bone diseaseosteoporosis screening

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Area of Science:

  • Immunology
  • Bone Metabolism
  • Biochemistry

Background:

  • Established osteoporosis risk factors include age, sex, and menopause.
  • Emerging research indicates immune cells influence bone metabolism.
  • The specific role of basophils in bone health is not well understood.

Purpose of the Study:

  • To investigate the association between peripheral blood basophil count and lumbar spine bone mineral density (BMD).
  • To explore potential correlations in an East Asian adult population.

Main Methods:

  • Retrospective analysis of 200 adults undergoing health check-ups.
  • Lumbar dual-energy X-ray absorptiometry (DXA) was used to assess BMD.
  • Multivariate regression analysis correlated basophil count and other parameters with lumbar spine T-scores.

Main Results:

  • No significant correlation was found between basophil count and lumbar spine T-scores in the overall cohort (r = 0.06, p = 0.4261).
  • A weak inverse trend was observed in participants with a Body Mass Index (BMI) ≥ 27.
  • Alanine aminotransferase (GPT) and creatinine were significantly associated with BMD; GPT was a strong independent predictor (β = 0.61, p < 0.001).

Conclusions:

  • Peripheral basophil count is unlikely to be a reliable biomarker for BMD in the general population.
  • Further research is warranted to explore the potential link between basophils and BMD in individuals with higher BMI.
  • Alanine aminotransferase (GPT) may serve as a valuable surrogate marker for bone health assessment in clinical settings.