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Telomerase Reverse Transcriptase-mutated Follicular Variant Papillary Thyroid Cancer With Tibial Metastasis
Nicole Chan1, Syed Gilani2, Grace Kim1
1Division of Endocrinology and Metabolism, Albany Medical College, Albany, NY 12208, USA.
JCEM Case Reports
|September 22, 2025
Summary
Follicular variant of papillary thyroid carcinoma (FV-PTC) with a TERT promoter mutation can metastasize aggressively to bone. This case highlights the importance of monitoring for late-onset recurrence in FV-PTC patients.
Area of Science:
- Oncology
- Endocrinology
- Genetics
Background:
- Follicular variant of papillary thyroid carcinoma (FV-PTC) typically has a good prognosis.
- Aggressive behavior and metastasis are associated with TERT promoter mutations in FV-PTC.
- Appendicular skeletal metastasis is rare in papillary thyroid carcinoma.
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