PMMA bone cement with AgNP@CDs nanocomposite for infection control and inflammation mitigation
Ihsan Ullah1,2,3, Jian Ju3, Yapei Song4
1Joint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China.
Regenerative Biomaterials
|September 22, 2025
Summary
This study introduces a novel silver nanoparticle-carbon dot (AgNP@CDs) enhanced poly(methyl methacrylate) bone cement. The composite material effectively combats bacterial infections and promotes tissue regeneration, offering a promising solution for orthopedic surgery.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Orthopedic Surgery
Background:
- Poly(methyl methacrylate) (PMMA) bone cement is widely used but susceptible to infection and bioinert.
- Limitations include bacterial colonization and lack of tissue integration support.
Purpose of the Study:
- To develop a PMMA-based bone cement incorporating a silver nanoparticle-carbon dot (AgNP@CDs) nanocomposite.
- To evaluate its efficacy in combating bacterial infections, minimizing cytotoxicity, and supporting tissue regeneration.
Main Methods:
- Incorporation of AgNP@CDs (2 wt%) into PMMA bone cement.
- Evaluation of antibacterial efficacy through in vitro and in vivo studies.
- Assessment of biocompatibility, cell proliferation, adhesion, migration, and histological analysis for inflammation and tissue integration.
Main Results:
- The PMMA@2Ag-CDs composite demonstrated significant antibacterial activity, reducing bacterial growth by up to 90%.
- Improved cell proliferation, adhesion, and migration compared to pure PMMA.
- Reduced inflammation and enhanced tissue integration with organized collagen deposition and angiogenesis.
Conclusions:
- The PMMA@2Ag-CDs composite offers a promising solution for preventing infections and mitigating inflammatory responses in orthopedic applications.
- Functionalization of bone cement with AgNP@CDs enhances biocompatibility and promotes tissue regeneration.
- This strategy holds potential for practical applications in orthopedic and trauma surgery.
