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  11. Precision Removal Of Uneven Skin Tissue At The Micrometer Level Via Focus-corrected Femtosecond-laser Ablation

Precision removal of uneven skin tissue at the micrometer level via focus-corrected femtosecond-laser ablation

Mingzhou Yuan1,2, Xu He3, Guangtao Huang1

  • 1Department of Burn and Plastic Surgery, Medical Innovation Technology Transformation Center, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, 3002 Sungang West Road, Futian District, Shenzhen 518035, China.

Burns & Trauma
|September 22, 2025

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View abstract on PubMed

Summary
This summary is machine-generated.

Focus-corrected femtosecond lasers (fs-lasers) enable precise, micrometer-level skin tissue removal, minimizing collateral damage. This innovative technique offers a safer, ultrahigh-precision surgical approach for skin and other tissues.

Area of Science:

  • Regenerative Medicine
  • Aesthetic Surgery
  • Biomedical Engineering

Background:

  • Precision surgical instruments are vital for preventing complications in aesthetic surgery and promoting tissue regeneration.
  • Femtosecond lasers (fs-lasers) offer micrometer-level tissue removal but struggle with uneven skin textures, causing defocusing and potential injury.
  • Overcoming fs-laser defocusing is crucial for safe and effective clinical application in dermatology and surgery.

Purpose of the Study:

  • To develop and evaluate a focus-corrected femtosecond laser (fs-laser) system for precise skin tissue ablation.
  • To investigate the impact of laser parameters on ablation depth and efficiency on uneven skin surfaces.
  • To assess the safety and efficacy of focus-corrected fs-laser ablation in a preclinical model.

Main Methods:

Keywords:
DebridementFemtosecond laserPrecision surgerySkin

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  • A self-developed fs-laser microfabrication platform with a focus-corrected method using 2D interpolation was employed.
  • Porcine skin was scanned using varying laser powers and velocities for linear, planar, and 3D ablation.
  • An in vivo rat model was used to evaluate precise tissue ablation, with histological analysis of remaining skin integrity and viability.

Main Results:

  • Focus-corrected fs-laser ablation achieved controllable micrometer-level skin tissue removal, with depth correlated to single-pulse energy.
  • Scanning velocity did not affect ablation depth due to the integrated focusing mechanism, unlike conventional laser devices.
  • Precise, rapid, and safe skin ablation was achieved in rats, with histological and biochemical analyses confirming no damage to collagen or cell viability.

Conclusions:

  • Focus-corrected fs-laser ablation enables micron-scale skin removal with minimal collateral damage.
  • Adjustable single-pulse energy allows for depth-specific ablation, while maximum scanning velocity ensures rapid operation.
  • This technique presents an innovative, ultrahigh-precision surgical approach for skin, other tissues, and organs.