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Successful sequential therapy for Stenotrophomonas maltophilia infection in a preterm neonate: a case report
Majed Nahari1,2, Mohammed Alaboud3,4, Syed Mohinuddin5,6
1Pharmaceutical Care Services, King Abdullah Bin Abdulaziz University Hospital, Riyadh, Saudi Arabia.
Background:
A multidrug-resistant pathogen increasingly seen in newborn intensive care units, stenotrophomonas maltophilia presents treatment difficulties for preterm babies.
Case Presentation:
A 28-week preterm neonate developed S. maltophilia sepsis following prolonged mechanical ventilation. Initial therapy with trimethoprim- sulfamethoxazole (TMP-SMX) was ineffective, prompting a switch to levofloxacin, which led to clinical recovery and infection clearance.
Conclusion:
This case highlights the need for tailored antimicrobial strategies in neonatal S. maltophilia infections. Sequential therapy with TMP-SMX and levofloxacin was effective, supporting the judicious use of fluoroquinolones in resistant cases.
