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Albuminuria is independently associated with preclinical left ventricular systolic dysfunction: The TESEO study
Federica Barutta1, Alessandro Andreis2,3,4, Matteo Bellettini2
1Department of Medical Sciences, University of Turin, Turin 10126, Italy. federica.barutta@unito.it.
World Journal of Diabetes
|September 22, 2025
Summary
In type 2 diabetes patients, albuminuria is linked to subclinical left ventricular systolic dysfunction (LVSD). This finding highlights albuminuria as an independent predictor of LVSD in this population.
Area of Science:
- Cardiology
- Diabetology
- Nephrology
Background:
- Global longitudinal strain (GLS) is a sensitive marker for left ventricular systolic dysfunction (LVSD), outperforming ejection fraction (EF).
- Albuminuria predicts heart failure in type 2 diabetes (DM2), but its association with GLS is debated.
Purpose of the Study:
- To investigate the relationship between GLS and albuminuria in a contemporary cohort of DM2 patients.
Main Methods:
- The TESEO study enrolled 193 DM2 patients, excluding those with heart failure symptoms, low EF, or cardiac disease.
- GLS was assessed using speckle-tracking echocardiography.
- Regression analyses identified predictors of GLS and assessed the independent association of albuminuria with GLS-diagnosed LVSD (GLS > -18%).
Main Results:
- 21.8% of patients had preclinical GLS-LVSD.
- GLS values were significantly better in patients with albuminuria (P < 0.001).
- Albuminuria was an independent predictor of GLS-LVSD (OR 6.01), even after adjusting for multiple clinical factors.
Conclusions:
- Albuminuria is independently associated with subclinical LVSD in DM2 patients.
- This association persists regardless of other risk factors, emphasizing the role of albuminuria in cardiac dysfunction.
Keywords:
AlbuminuriaGlobal longitudinal strainHeart failureLeft ventricular systolic dysfunctionType 2 diabetesMore Related Videos
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