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CYP2C8-Mediated Drug-Drug Interactions and the Factors Influencing the Interaction Magnitude

Ling-Ling Zhu1, Ling-Yan Yu2, Yan-Hong Wang2

  • 1VIP Care and Geriatric Ward, Division of Nursing, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.

Drug Design, Development and Therapy
|September 22, 2025
PubMed
Summary

Cytochrome P450 (CYP) 2C8 is an important enzyme for drug metabolism, but its drug-drug interactions (DDIs) are often overlooked. This review details CYP2C8 substrates, inhibitors, inducers, and factors influencing DDI magnitude, crucial for safe medication use in older adults.

Keywords:
cytochrome P450 2C8drug interactionsolder adultspharmacokineticssafety

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