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BimABm positivity in melioidosis and its impact on clinical profile, and outcomes: a retrospective cohort study
Nitin Gupta1, Tirlangi Praveen Kumar1, Soumi Chowdhury2
1Department of Infectious Diseases, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal 576104, Karnataka, India.
Objectives:
Melioidosis, caused by Burkholderia pseudomallei presents with diverse clinical features. Neurological involvement, though rare, is a severe complication. The BimABm allele, a variant of the Burkholderia intracellular motility A (BimA) virulence gene, has been linked to neurotropism, but data from India on this association are limited.
Methods:
We conducted a retrospective cohort study of 138 culture-confirmed melioidosis patients at a tertiary care center in southern India. A polymerase chain reaction assay was used to detect the BimABm allele in archived isolates. Clinical features and 28-day mortality were compared between BimABm -positive and -negative groups.
Results:
The BimABm allele was detected in 5.8% of isolates. Neurological involvement was significantly more common in BimABm-positive patients (50% [4/8] vs 2.3% [3/130], P < 0.001). No significant differences in comorbidities or 28-day mortality were observed between the two groups.
Conclusions:
Although uncommon, the BimABm allele is strongly associated with neurological melioidosis in southern India.
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