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Related Concept Videos

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Updated: Jan 17, 2026

Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Normothermic Kidney Perfusion: Current Status and Future Perspectives.

Barbara Franchin1, Leonie van Leeuwen2, Matthew L Holzner2

  • 1Renal Division, Department of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Kidney International Reports
|September 22, 2025
PubMed
Summary
This summary is machine-generated.

Normothermic machine perfusion (NMP) offers a promising approach for kidney preservation, enhancing viability assessment and potentially reconditioning marginal donor kidneys. Wider clinical use requires standardization of NMP devices and protocols.

Keywords:
ex situ perfusiongraft recoveryischemia-reperfusion injurykidney transplantationmarginal donorstarget-therapies

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Area of Science:

  • Transplantation
  • Organ Preservation
  • Machine Perfusion

Background:

  • Normothermic machine perfusion (NMP) is an advanced method for maintaining organs ex situ in a physiologically active state.
  • While widely used for liver, heart, and lung preservation, NMP application in kidney transplantation is less common.
  • NMP presents an opportunity to improve the utilization of marginal donor kidneys.

Purpose of the Study:

  • To review the current status of NMP in kidney transplantation.
  • To explore the potential of NMP for graft reconditioning and viability assessment.
  • To discuss challenges hindering broader clinical implementation of kidney NMP.

Main Methods:

  • Literature review of studies on kidney normothermic machine perfusion.
  • Analysis of NMP's role in assessing and potentially restoring kidney graft function.
  • Examination of NMP as a platform for studying organ injury and recovery markers.

Main Results:

  • NMP can enhance viability assessment and potentially recondition marginal donor kidneys for transplantation.
  • NMP serves as a platform for targeted therapies to modulate immunologic or transcriptomic profiles.
  • Variability in NMP devices, protocols, and perfusates currently challenges cross-study comparisons.

Conclusions:

  • Kidney NMP shows significant promise for expanding the donor pool and improving outcomes.
  • Standardization of NMP protocols and devices is crucial for wider clinical adoption.
  • Further research is needed to fully realize the potential of NMP in kidney transplantation and graft reconditioning.