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Related Concept Videos

Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Renal Corpuscle01:20

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The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Updated: Jan 17, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
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An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

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Lower Podocyte Number per Glomerulus Associates With Progressive CKD.

Aleksandar Denic1, Afsana A Shaik1, Syed Khooshal Fareeduddin1

  • 1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Kidney International Reports
|September 22, 2025
PubMed
Summary
This summary is machine-generated.

Low podocyte number is linked to progressive chronic kidney disease (CKD) development. This finding holds true regardless of other risk factors, kidney function, or disease severity, offering new insights into kidney disease progression.

Keywords:
chronic kidney diseaseepidemiologyglomerulusparietal epithelial cellpodocytestereology

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Area of Science:

  • Nephrology
  • Pathology
  • Clinical Research

Background:

  • Podocyte depletion is implicated in chronic kidney disease (CKD) pathogenesis.
  • Longitudinal studies in non-obesity-related glomerulopathy populations are scarce.

Purpose of the Study:

  • To investigate the association between podocyte number and the development of progressive CKD.
  • To evaluate podometric and parietal epithelial cell (PEC) measures in relation to CKD progression.

Main Methods:

  • Retrospective analysis of patients undergoing radical nephrectomy.
  • Identification of progressive CKD cases based on defined renal function decline or renal replacement therapy.
  • Immunohistochemistry and stereology used for podocyte and PEC quantification.
  • Statistical analysis adjusted for multiple clinical and histological factors.

Main Results:

  • Lower podocyte number and density were observed in patients with progressive CKD compared to controls.
  • Podocyte number correlated with nephrosclerosis measures.
  • Adjusted analyses confirmed an association between podocyte number/density and progressive CKD.

Conclusions:

  • Reduced podocyte number per glomerulus is independently associated with progressive CKD.
  • Podocyte number is a significant predictor of CKD progression, irrespective of other risk factors and disease severity.