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Cardiovascular Complications in ADPKD.

Niloufar Ebrahimi1, Yasar Caliskan2, Pranav S Garimella3

  • 1Department of Medicine, Division of Nephrology, Loma Linda University Medical Center, Loma Linda, California, USA.

Kidney International Reports
|September 22, 2025
PubMed
Summary
This summary is machine-generated.

Autosomal dominant polycystic kidney disease (ADPKD) significantly increases cardiovascular disease risk, a major cause of mortality. Early detection and management of these cardiovascular issues are crucial for improving patient outcomes.

Keywords:
autosomal dominant polycystic kidney diseasecardiovascular complicationshypertensionleft ventricular hypertrophyvalvular abnormalities

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Area of Science:

  • Nephrology
  • Cardiology
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary kidney disease.
  • Cardiovascular disease is the leading cause of mortality in ADPKD patients.
  • ADPKD involves extrarenal manifestations, notably cardiovascular complications.

Purpose of the Study:

  • To review cardiovascular complications in ADPKD.
  • To emphasize the importance of early detection of cardiovascular manifestations.
  • To provide an overview of management strategies for ADPKD patients with cardiovascular disease.

Main Methods:

  • Literature review of cardiovascular manifestations in ADPKD.
  • Analysis of the interplay between ADPKD genetics and cardiovascular disease.
  • Exploration of early and late-onset cardiovascular complications.

Main Results:

  • Hypertension, left ventricular hypertrophy, diastolic dysfunction, valvular abnormalities, aortic aneurysm, and pericardial effusion are common.
  • Cardiovascular manifestations can occur early due to genetic factors or later with chronic kidney disease progression.
  • Hypertension in ADPKD involves polycystin dysfunction, signaling disruptions, and RAAS activation.

Conclusions:

  • Cardiovascular complications are a significant concern in ADPKD.
  • Early detection and tailored management are vital for improving outcomes.
  • Understanding the mechanisms driving cardiovascular disease in ADPKD is key for effective treatment.