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Tacrolimus-Associated Hyperpigmentation: A Case Report and Literature Review
Bryan Tassavor1, Rishi Chopra2
1Osteopathic Medicine, A.T. Still University School of Osteopathic Medicine, Mesa, USA.
Cureus
|September 22, 2025
Summary
Topical tacrolimus can cause paradoxical hyperpigmentation, a rare side effect in vitiligo patients. This case highlights the importance of monitoring pigmentary changes during treatment with this immunomodulator.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Topical tacrolimus is a calcineurin inhibitor widely used for managing vitiligo.
- Vitiligo is a chronic autoimmune condition characterized by depigmented patches.
- Immunomodulators can sometimes cause paradoxical pigmentary changes.
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