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Related Concept Videos

Decreased pulse rate01:14

Decreased pulse rate

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Bradycardia is a medical condition in which the heart rate is slower than normal. It occurs when the heart's natural pacemaker, the sinus node, generates slower electrical impulses than the standard rhythm. In adults, bradycardia is diagnosed when the pulse rate falls below 60 beats per minute, indicating a deviation from the normal heart rate range.
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Factors Influencing Heart Rate01:30

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The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
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Increased pulse rate01:17

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Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
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Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
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Heart Failure III: Clinical Manifestations01:26

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Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
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Regulation of Heart Rates01:31

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The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
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Decreased Heart Rate Variability Is Associated with Increased Fatigue Across Different Medical Populations: A

Sophie Maria Penfold1, James Cunningham1, Pauline Whelan1

  • 1School of Health Sciences, Faculty of Biology, Medicine and Health, Division of Informatics, Imaging and Data Sciences, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|September 22, 2025
PubMed
Summary

This review found that increased fatigue is linked to autonomic dysfunction, indicated by heart rate variability (HRV) changes. Higher sympathetic activity and lower parasympathetic tone correlate with greater fatigue perception in patients.

Keywords:
fatigueheart rate variabilitymedical conditionsmedical populations

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Area of Science:

  • Autonomic Nervous System Research
  • Clinical Physiology
  • Systematic Review Methodology

Background:

  • Fatigue negatively impacts quality of life and increases morbidity across various medical conditions.
  • Autonomic dysfunction is associated with poor health outcomes, including higher comorbidity and mortality risks.
  • Heart rate variability (HRV) is a validated measure of autonomic function in clinical settings.

Purpose of the Study:

  • To systematically review and synthesize the existing literature on the relationship between fatigue and heart rate variability (HRV) in diverse patient populations.
  • To identify patterns and inconsistencies in how fatigue and autonomic function are measured and associated in medical research.

Main Methods:

  • A comprehensive systematic literature search was performed using major scientific databases (MEDLINE, Web of Science, Scopus).
  • Seventeen articles met the inclusion criteria, focusing on populations such as Chronic Fatigue Syndrome, cancer, and Multiple Sclerosis.
  • Data extraction focused on fatigue assessment tools, HRV measurement techniques (predominantly electrocardiogram), and HRV domains (frequency parameters).

Main Results:

  • Fourteen of the seventeen studies reported a significant association between increased subjective fatigue and altered HRV metrics (p < 0.05).
  • Chronic Fatigue Syndrome was the most studied group, followed by cancer and Multiple Sclerosis patients.
  • Heterogeneity in findings was noted due to variations in fatigue and HRV measurement instruments, and limited population diversity (predominantly older adults and women).

Conclusions:

  • The reviewed evidence indicates a consistent association between heightened sympathetic activity, reduced parasympathetic tone, and an increased perception of fatigue in medical populations.
  • Despite methodological inconsistencies, the findings suggest a physiological basis for fatigue related to autonomic imbalance.
  • Further research with standardized methodologies and diverse populations is warranted to solidify these findings.