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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Catatonia in Systemic Lupus Erythematosus.
Ciro Manzo1, Jordi Serra-Mestres2, Marco Isetta3
1Internal and Geriatric Medicine Department, Azienda Sanitaria Locale Napoli 3 Sud, Health District No. 59, Viale dei Pini 1, Sant'Agnello, 80065 Naples, Italy.
Neurosci
|September 22, 2025
Summary
Catatonia is a rare but significant manifestation of Systemic Lupus Erythematosus (SLE), often appearing early in young patients. Treatment with lorazepam and electroconvulsive therapy generally leads to favorable outcomes.
Area of Science:
- Rheumatology
- Psychiatry
- Neurology
Background:
- Systemic lupus erythematosus (SLE) is linked to catatonia, though reports are infrequent.
- A comprehensive understanding of catatonia in SLE patients is lacking.
- This review aims to consolidate existing literature on catatonia in SLE.
Purpose of the Study:
- To identify all published reports of catatonia in SLE patients.
- To comprehensively analyze the clinical characteristics of catatonia in SLE.
- To provide practical insights for clinical management.
Main Methods:
- Conducted comprehensive literature searches across major databases (MEDLINE, EMBASE, PsycINFO, PubMed).
- Utilized combined controlled and free-text search terms for SLE and catatonia.
- Focused on case reports and series, with manual citation tracking for additional references.
Main Results:
- Identified 39 cases of SLE with catatonia (mean age 22.64 years; 35 females).
- Catatonia occurred at SLE onset in 10 patients and within one month of diagnosis in 5.
- Most patients improved with lorazepam and/or electroconvulsive therapy; malignant catatonia was rare.
Conclusions:
- Catatonia can be an initial presentation of SLE, particularly in younger individuals.
- The prognosis for catatonia in SLE patients is generally favorable.
- Early recognition and treatment are crucial for positive outcomes.
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